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海藻硫酸多糖的分离纯化及其抗肿瘤作用

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(日照市人民医院,山东  日照,276800

中图分类号:R285.5       文献标识码:A    文章编号:1674-7860(2016)18-0031-02  

 】目的:探讨海藻硫酸多糖的分离纯化及其抗肿瘤作用。方法:选取鼠龄、质量大致相同的昆明种雄性小鼠60只,随机分为5组,正常对照组、阳性对照组、低剂量组、中剂量组和高剂量组,每组12只。低剂量组、中剂量组和高剂量组分别注射浓度为25mg/ kg50 mg/ kg100 mg/ kg的海藻硫酸多糖,氟脲嘧啶20mg/kg注射阳性对照组,正常对照组采用生理盐水溶液注射,比较各组小鼠的抑瘤率。结果:低剂量组、中剂量组、高剂量组和阳性对照组小鼠的抑瘤率分别为5.0%22.3%27.9%50.3%,阳性对照组的抑瘤率明显高于其他三组,高剂量组的抑瘤率明显高于低剂量组和中剂量组,中剂量组的抑瘤率明显高于低剂量组,组间比较差异具有统计学意义(P0.05)。结论:海藻硫酸多糖具有显著的抗肿瘤作用。

关键词】海藻硫酸多糖;分离纯化;抗肿瘤作用

AbstractObjective:To explore the separation and purification of algae sulfated polysaccharide andits anti-tumor effect. Methods:60 Kunming male mice ofsimilar age and quality were selected and randomly divided into 5 groups: thenormal control group, the positive control group, low dose group, middle dosegroup and high dose group, with 12 rats in each group. Low-dose group, middledose group and high dose group were injected at a concentration of 25mg / kg,50mg / kg, 100mg / kg of seaweed sulfated polysaccharide respectively, thepositive control group was given fluorouracil 20 mg / kg injection while the normalcontrol group was injected with saline solution, inhibitory rate of each groupof mice was compared. Results: The inhibition rate of low-dose group, middledose group, high dose group and the positive control group was 5.01%, 22.3%,27.9% and 50.3% respectively, the inhibition rate of the positive control groupwas significantly higher than that of the other three groups, the inhibitionrate of high-dose group was significantly higher than that of the low dosegroup and middle dose group, the inhibition rate of middle dose wassignificantly higher than the low-dose group, the difference between the groupswas statistically significant (P<0.05). Conclusion: Seaweed sulfated polysaccharides had significantanti-tumor effect.

KeywordsSeaweedsulfated polysaccharides; Isolation and purification; Antitumor effect

doi:10.3969/j.issn.1674-7860.2016.18.013


详情请浏览《中医临床研究》2016第18期‍

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