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疏肝理脾祛风汤联合盐酸非索非那定片治疗慢性荨麻疹肝郁脾虚证的临床疗效

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1  蔡玲玲2  李元文2*

1.怀柔区中医医院,北京,1014002.北京中医药大学东方医院,北京,100078

类号:R758.24    献标识码:A    文章编号:1674-7860(2016)18-0015-04    :IDGA

【摘  要】目的:观察疏肝理脾祛风汤合并盐酸非索非那定片治疗慢性荨麻疹肝郁脾虚证的临床疗效。方法:采用随机分组对照法将20154月—201512在我院皮肤科就诊的慢性荨麻疹肝郁脾虚型患者60例分为观察组和对照组各30例。观察组给予疏肝理脾祛风汤联合盐酸非索非那定片治疗;对照组单纯给予口服盐酸非索非那定片治疗。2周为1个疗程,共2个疗程。观察临床疗效、全身症状及皮损症状的缓解情况。结果:①观察组总有效率为93.3%,明显优于对照组的76.7%。两组之间差异明显P0.05有统计学意义。②两组在治疗后均能有效控制患者总体症状,都是有效治疗药物。并且观察组疗效优于对照组。两组治疗前后在瘙痒程度、发作频率、皮肤划痕症、皮损分布、持续时间、风团大小、风团数量等指标中,P0.05均有显著性差异,观察组明显优于对照组,更能改善荨麻疹的局部症状及全身症状,提高患者生活质量。③停药1个月后随访发现观察组复发率13.3%,对照组30%,两组比较有显著差异P0.05。结论:疏肝理脾祛风汤联合盐酸非索非那定片治疗慢性荨麻疹肝郁脾虚证,临床疗效好,能改善此证的全身症状及皮损症状,不良反应少,复发率低,安全可靠,值得临床推广。

【关健词】慢性荨麻疹;疏肝理脾祛风汤;盐酸非索非那定片

AbstractObjective:To observe the clinical effect ofShugan Lipi Qufeng decoction combined with fexofenadine hydrochloride tabletsin treating chronic urticaria liver qi stagnation and spleen deficiencysyndrome. Methods: 60 patients with chronic urticaria liver qi stagnation andspleen deficiency syndrome, who were treated in the dermatological departmentof our hospital from April 2015 to December 2015, were randomly divided intothe observation group and the control group, with 30 cases in each group. Theobservation group received Shugan Lipi Qufeng decoction combined withfexofenadine hydrochloride tablets while the control group only receivedfexofenadine hydrochloride tablets. Two weeks formed one course and thetreatment lasted two courses. The clinical effect and the relief of systemicsymptoms and skin lesions were observed. Results: Thetotal effective rate of the observation group was 93.3%,which was significantly higher than that of the control group, 76.7%, the difference between twogroups was statistically significant (P< 0.05). After treatment, the general symptoms of the patient of two groups werecontrolled and the treatments were all effective, but the clinical effect of theobservation group was better than that of the control group. There weresignificant differences in indexes such as degree of itching, seizurefrequency, skin scratch disease, skin lesions distribution, duration and thesize and number of wheals before and after treatment (P < 0.05), the observation group was better than the controlgroup in improving the local symptoms and systemic symptoms and enhancing thequality of life of urticaria patients. Follow up 1 month afterstopping taking drug showed that the recurrence rate of the  observation group and the control group was 13.3%and 30% respectively, the difference between two groups was statisticallysignificant (P < 0.05).Conclusion: Shugan Lipi Qufeng decoction combined with fexofenadinehydrochloride tablets had good clinical effect in treating chronic urticarialiver qi stagnation and spleen deficiency syndrome; it could relieve thesystemic symptoms and skin lesions and was of less adverse reaction and lowrecurrence rate, which was safe and reliable, therefore, it was worthy ofclinical promotion.

KeywordsChronicurticaria; Shugan Lipi Qufeng decoction; fexofenadine hydrochloride tablets

doi:10.3969/j.issn.1674-7860.2016.18.007


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