培美曲塞二钠、吉非替尼交替使用与序贯使用在EGFR突变型晚期老年肺腺癌的临床疗效观察

陈永锋  李媛媛    

（广东省农垦中心医院，广东  湛江，524002）

中图分类号：R734.2    文献标识码：A    文章编号：1674-7860(2015)33-0136-02    证型：IDGB

【摘  要】目的：观察培美曲塞、吉非替尼交替使用与序贯使用在EGFR突变型晚期老年肺腺癌的临床疗效。方法：选取2013年10月—2015年1月我院收治的EGFR突变型晚期老年肺腺癌70例作为研究对象，随机分为观察组35例，对照组35例，对照组患者给予培美曲塞与吉非替尼交替使用治疗，观察组患者给予培美曲塞、吉非替尼序贯治疗，比较两组患者近期疗效、远期疗效及不良反应变化。结果：两组患者近期疗效比较，观察组部分缓解及稳定例数高于对照组，差异有统计学意义（P＜0.05）；两组患者PFS及OS远期疗效指标比较，差异无统计学意义（P＞0.05）；两组患者不良反应比较，差异无统计学意义（P＞0.05）。结论：培美曲塞、吉非替尼交替使用与序贯使用治疗EGFR突变型晚期老年肺腺癌，近期疗效及远期疗效良好，临床应用安全性高。

【关键词】肺腺癌；培美曲塞；吉非替尼

【Abstract】Objective: To observe the clinical effectobservation of the alternative and sequential application of pemetrexeddisodium and gefitini in treating EGFR mutant advanced aged lungadenocarcinoma. Methods: 70 patients with EGFR mutant advanced aged lungadenocarcinoma, admitted to our hospital from October 2013 to January 2015, wererandomized into the observation group and the control group evenly. The control group received alternativeapplication of pemetrexed disodium and gefitini while the observation groupreceived sequential application of pemetrexed disodium and gefitini, the shortterm effect, long term effect and the adverse reaction of two groups werecompared. Results: As for the short term effect, the relieved and stabilizedcases of the observation group excelled that of the control group, thedifference was statistically significant (P<0.05);As for the long term effect, the difference of PFS and OS indexes in two groupswas not statistically significant (P＞0.05); As for the adverse reaction, the difference oftwo groups was not statistically significant (P＞0.05). Conclusion: The alternative andsequential application of pemetrexed disodium and gefitini had both good shortterm effect and long term effect in addition to a high clinical security intreating EGFR mutant advanced aged lung adenocarcinoma.  

【Keywords】Lungadenocarcinoma; Pemetrexed disodium; Gefitini

doi:10.3969/j.issn.1674-7860.2015.33.067

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