穿心莲软胶囊与穿心莲片的药理作用 及急性毒性实验研究
钟晓凤
（三门峡市中医院，河南 三门峡，472000）
中图分类号：R258.5 文献标识码：A 文章编号：1674-7860(2015)24-0140-02 证型：I
【摘 要】目的：研究对比穿心莲软胶囊与穿心莲片的药理作用及穿心莲软胶囊的毒性。方法：本文以大鼠为实验对象，分别对大鼠使用细菌脂多糖进行发热实验、啤酒酵母能够辅助发热实验进行，穿心莲胶囊对发热大鼠使用后，能够起到散热效果，并对数据进行观察；此外，对小鼠采用角叉菜胶进行肿胀实验，二甲苯与醋酸辅助肿胀实验进行，增加小鼠腹腔毛细血管的通透性，之后对小鼠使用穿心莲胶囊，对肿胀小鼠的抗炎症效果进行分析观察。结果：穿心莲软胶囊的散热作用明显高于穿心莲片，中剂量的穿心莲软胶囊的消炎作用显著高于穿心莲片，P＜0.05。研究发现，小鼠的每日最大毒性耐受量是110.25 g/kg，是成人日用量的525倍。结论：穿心莲软胶囊具备良好的散热和抗炎作用，而且没有明显的毒副作用。
【关键字】穿心莲软胶囊；穿心莲片；药理作用；毒性实验
【Abstract】Objective:To study and compare thepharmacological effects of andrographis soft capsules and andrographis Tabletand toxicity of andrographis soft capsules. Methods: Rats were taken as theexperimental objects. Lipopolysaccharide was used fot the fever experiment and beeryeast was the assistant in the fever experiment. After the fever experiment, andrographiscapsules were given to the fever rats to dissipate heat and the data wereobserved. In addition, swelling experiments on mice were done by carrageenan, withxylene and acetic acid as the assistant. The peritoneal capillary permeability ofthe mice were increased. And then andrographis capsules was used to resist inflammationand the anti-inflammatory effect was observed. Results: The effect dissipatingheat of andrographis soft capsules was significantly higher than that of andrographistablets and the anti-inflammatory effect of andrographis soft capsules in middledose was significantly higher than that of andrographis tablets, P<0.05. It was found that the dailymaximum toxicity tolerance in mice is 110.25 g/kg which is 525 times of adultdosage. Conclusion: Andrographis soft capsules have good heat-dissipating andanti-inflammatory effect and no obvious side effects.
【Keywords】Andrographis Soft Capsules; Andrographis Tablets;Pharmacological Effect; Toxicity Experiment
doi:10.3969/j.issn.1674-7860.2015.24.067
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