超声药物透入疗法防治 卡培他滨相关性手足综合征35例
超声药物透入疗法防治
卡培他滨相关性手足综合征35例
Prevention and treatment of 35 cases with capecitabinehand-foot-related
syndrome by ultrasound drug penetration therapy
闻飞飞1 赵美随2
（1. 北京市大兴区旧宫医院，北京，100076；2.北京市大兴区普祥中医肿瘤医院，北京，100076）
中图分类号：R738.5 文献标识码：A 文章编号：1674-7860(2015)18-0142-03 证型：IDGB
【摘 要】目的：观察超声药物透入疗法预防及治疗卡培他滨所致手足综合征（hand footsyndrom e, HFS）的疗效。方法：选取卡培他滨化疗患者共35例，35例均为经病理学或细胞学确诊的乳腺癌、结肠癌、胃癌患者。随机分为试验组18例和对照组17例。卡培他滨每日量为2500 mg/m2，分2次口服，连用14 d，休息7 d，21 d为1个周期。预防组18例，化疗同时运用超声药物透入仪导入维生素B6注射液，隔日1次。对照组17例，化疗同时给予维生素B6口服至化疗结束。结果：试验组18例患者中3例发生Ⅰ级手足综合征，发生率为16.7%，对照组手足综合征发生率为44.4%，两者有显著性差异（P<0.05）。结论：超声药物透入疗法可有效防治卡培他滨化疗所致手足综合征。
【关键词】手足综合征；超声药物透入疗法；卡培他滨
【Abstract】Objective:To investigate the effects of prevention and treatment of ultrasound therapydrug penetration on capecitabine induced hand-foot syndrome (hand foot syndromee, HFS) [1] .Methods: 35 caseswith capecitabine chemotherapy confirmed by pathology or cytology of breastcancer, colon cancer, stomach cancer were selected and randomly divided into anexperimental group with 18 cases and a control group with 17 cases. The amountof capecitabine was 2500 mg / m2, twice orally, 14 days continuously,rest 7 days, 21 days for a period.18 patients in the prevention group weretreated with ultrasound drug penetration instrument imported vitamin B6injection, every other day, while 17 cases in the control group were treatedwith vitamin B6 oral chemotherapy until the end of chemotherapy.Results: 3 cases among 18 patients in the experimental groupoccurredⅠgrade hand-foot syndrome, the rate was 16.7%, while that in thecontrol group hand-foot syndrome was 44.4% with significant difference (P<0.05).Conclusion: Ultrasound drugpenetration therapy can effectively control capecitabine chemotherapy inducedhand-foot syndrome.
【Keywords】Hand-footsyndrome;Ultrasound therapy drug penetration;Capecitabine
doi:10.3969/j.issn.1674-7860.2015.18.073
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