羟乙基淀粉200注射液治疗小血管病变导致的 后循环缺血性眩晕的疗效观察

张振芳  司秋霞  王 雯  赵 娜  黄 静

（沧州市中西医结合医院，河北  沧州，061001）

中图分类号：R741      文献标识码：A    文章编号：1674-7860（2016）12-0042-04   证型：BDG

【摘  要】目的：观察羟乙基淀粉200注射液治疗小血管病变导致的后循环缺血性眩晕（PosteriorCirculation Ischemic Vertigo，PCIV）的临床疗效。方法：选取2014年1月—2014年12月在我院脑病科住院的90例经头MRI、MRA、DWI确诊的后循环缺血性眩晕患者，随机分为羟乙基淀粉治疗组45例和对照组45例，观察治疗前及治疗后7 d、（14±2） d，眩晕评估评分量表（DizzinessAssessment Rating Scale，DARS）评分、眩晕障碍调查表（DizzinessHandicap Inventory，DHI）评分及经颅多普勒超声（transcranialDoppler sonography，TCD）、脑干听觉诱发电位（Brainstem AuditoryEvoked Potential，BAEP）的变化。结果：羟乙基淀粉扩容治疗组较对照组，能明显改善眩晕患者的临床症状，两组患者DARS评分和DHI评分，两组均呈下降趋势，组间差异明显（P＜0.01）；两组患者TCD的变化结果，治疗前扩容治疗组异常率为82.2%（37/45），对照组治疗前异常率为86.7%（39/45），治疗后扩容治疗组异常率为15.7%（7/45），对照组异常率为37.8%（17/45）；两组均呈下降趋势，但扩容治疗组下降更明显，组间差异具有统计学意义；BAEP的变化，治疗前扩容治疗组异常率为77.78%（35/45），对照组治疗前异常率为71.1%（24/45），治疗后扩容治疗组异常率为17.8%（8/45），对照组异常率为42.2%（19/45）；两组异常率均呈有所下降，组间差异具有统计学意义。结论：羟乙基淀粉200/0.5注射液能够快速、有效地改善小血管病变导致的后循环缺血的症状。

【关键词】羟乙基淀粉200注射液；小血管病变；扩容治疗；后循环缺血性眩晕

【Abstract】Objective: To observe the clinical efficacy ofhydroxyethyl starch injection in the treatment of 200 small vascular lesionscaused by posterior circulation ischemic vertigo (posterior circulationischemic vertigo, PCIV). Methods: 90 cases diagnosed with posterior circulationischemic vertigo in our hospital between January 2014 toDecember 2014 in encephalopathy department after the headMRI, MRA, DWI were randomly divided into treatment group and control group, 45cases each group. Hydroxyethyl starch were observed 7 days before and aftertreatment, and vertigo Assessment Rating Scale (Dizziness Assessment RatingScale, DARS) score, vertigo disorder questionnaire (Dizziness HandicapInventory, DHI) score and transcranial Doppler sonography  (TCD) and Brainstem auditory evoked potential(BAEP) changes were observed after (14±2) days of treatment . Results: Hydroxyethylstarch expansion in Treatment group can significantly improve the clinicalsymptoms in patients with vertigo than those in the control group. DARS ratingand DHI scores in both groups declined and the differences between the groupswere significant (P＜0.01). TCD changes were observed in both groups aftertreatment, abnormal rate before treatment were 82.2% (37/45) and 86.7% (39/45), respectively, intreatment group and control group, and the values after treatment were 15.7%(7/45) and 37.8% (17/45); Decline was observed in both groups, but the declinein the  treatment group were moreobvious, and the difference between group was statistically significant.Abnormal BAEP changes were observed in both groups, before the treatmentabnormal rate were 77.8% (35/45) and 71.1% (24/45), respectively, in thetreatment group and control group, and the values after treatment were 17.8%(8/45) and 42.2% (19/45); Abnormal rate were decreased in both groups, andthere was significant difference between the groups. Conclusion: hydroxyethylstarch injection can quickly and efficiently improve the 200/0.5 small vascularlesions caused by posterior circulation ischemia symptoms.

【Keywords】200 injection hydroxyethyl starch; Small vascularlesions; Volume expansion therapy; Posterior circulationischemic vertigo

doi:10.3969/j.issn.1674-7860.2016.12.020

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