白介素类因子及肿瘤坏死因子-α 在小儿肺炎支原体肺炎中的检测意义

全碧波  赵霞

（南阳医学高等专科学校，河南  南阳，473061）

中图分类号：R256.11    文献标识码：A    文章编号：1674-7860（2016）18-0095-02    证型：IDGB

【摘  要】目的：探讨白介素类因子及肿瘤坏死因子-α在小儿肺炎支原体肺炎中的检测意义。方法：选择我院收治的肺炎支原体肺炎患儿60例，作为观察组，同时选择在我院体检健康儿童50例作为对照组。测得上述对象白介素-6、白介素-8、白介素-10及肿瘤坏死因子-α水平。结果：观察组治疗前的白介素-6、白介素-8、白介素-10及肿瘤坏死因子-α水平高于对照组，差异有统计学意义（P＜0.05）。观察组治疗后的白介素-6、白介素-8、白介素-10及肿瘤坏死因子-α水平和对照组比较，差异无统计学意义（P＞0.05）。合并有肺纤维化样改变患儿胸腔积液白介素-8、肿瘤坏死因子-α水平高于本组血清胸腔积液白介素-8、肿瘤坏死因子-α水平，差异有统计学意义（P＜0.05）；合并有肺纤维化样改变患儿胸腔积液白介素-8、肿瘤坏死因子-α水平高于无纤维化样改变患儿，差异有统计学意义（P＜0.05）。结论：白介素-6、白介素-8、白介素-10及肿瘤坏死因子-α在儿童肺炎支原体肺炎发病早期其水平升高，检测其水平有助于临床诊断，有助于了解此类患儿预后。

【关键词】小儿；肺炎支原体肺炎；白介素-6；白介素-8；白介素-10；肿瘤坏死因子-α

【Abstract】Objective:To investigate interleukin-class factor and tumor necrosis factor-α for the detection of children withMycoplasma pneumoniae pneumonia. Methods: 60 casesadmitted to our hospital withMycoplasma pneumoniae pneumonia were taken as observation group, while 50 casesof healthy children were taken as a control group. The interleukin-6,interleukin-8, interleukin-10 and tumor necrosis factor-α levels were measured in both groups. Results: The pre-treatmentvalue of interleukin-6, interleukin-8, interleukin-10 and tumor necrosis factor-α levels werehigher, andthe differencewas statistically significant (P<0.05).The values of interleukin-6, interleukin-8, interleukin-10 and tumor necrosisfactor-α levels in the observationgroup after treatment and the control groupshowed statisticallyinsignificantdifferences (P>0.05). Associatedwith pleural effusion in children with pulmonary fibrosis-like changes ininterleukin-8, tumor necrosis factor -α higher than the present level of serumpleural fluid interleukin-8, tumor necrosis factor-α levels, the difference was statistically significant (P<0.05); associated with pulmonaryfibrosis-like changes in children with pleural fluid interleukin-8, tumornecrosis factor-α higher thanchildren with no fibrosis-like changes, the difference was statisticallysignificant (P <0.05). Conclusion:interleukin-6, interleukin-8, interleukin-10 and tumor necrosis factor-α raising its level in the early onsetof childhood detects the pneumonia mycoplasma pneumonia, detected levelscontribute to clinical diagnosis, prognosis is helpful to understand thesechildren.

【Keywords】Infant;Mycoplasma pneumoniae pneumonia; Interleukin-6; Interleukin-8; Interleukin-10;Tumor necrosis factor-α

doi:10.3969/j.issn.1674-7860.2016.18.045